Bounty hunter George Wolfe arrives in Medicine Bow to receive information on a man with a $5000 bounty on his head for murder. However, the man is killed in a wagon accident during a rain storm while being helped by Trampas and two men. Wolfe must wait until the man's bank lockbox is opened in two weeks. He suspects someone and especially Trampas may have killed the man to protect his identity. Trampas believes it is him due to an old charge against him for a robbery and murder he didn't actually commit. The Virginian persuades him to stay at Shiloh but in meantime a typhoid fever epidemic breaks out tied to strawberries washed with contaminated water. The local doctor is busy finding the source and handling the sick. Wolfe himself is struck down by the fever while stalking Trampas who takes him to Shiloh where the doctor tends to the hard hearted Wolfe. The lockbox is opened and Wolfe finally learns who the man is he is seeking but it is not Trampas.